N-bromobutanimide → 1-Bromo-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline

반응식

[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[C:7]([CH3:16])[C:8]3[N:9]2[CH:12]=[N:13][C:14]=3[CH3:15])=[CH:4][CH:3]=1.C1C(=O)N([Br:24])C(=O)C1>>[Br:24][C:12]1[N:9]2[C:10]3[C:5]([N:6]=[C:7]([CH3:16])[C:8]2=[C:14]([CH3:15])[N:13]=1)=[CH:4][CH:3]=[C:2]([F:1])[CH:11]=3

참가 물질

반응물 2

HCID 67184N-bromobutanimide

HCID 577324598-Fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline

생성물 1

HCID 577324521-Bromo-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline수율 89%

실험 절차

Reaction of intermediate 4A (1.55 g, 7.2 mmol) and NBS (1.92 g, 10.8 mmol) provided the product 5A as an off-white solid (1.87 g, 89% yield). EIMS 293.9 [M+H]+.

출처 및 근거

ORD 기록: ord-2870e4b00688498ab67c8c12701b213e
출처 데이터셋: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07875618B2

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