Potassium Carbonate → 1-(2,4-Difluorophenyl)-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline

HRID 254298

반응식

HRID 254298 반응식
Br[C:2]1[N:6]2[C:7]3[C:12]([N:13]=[C:14]([CH3:15])[C:5]2=[C:4]([CH3:17])[N:3]=1)=[CH:11][CH:10]=[C:9]([F:16])[CH:8]=3.[F:18][C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=1B(O)O.C([O-])([O-])=O.[K+].[K+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[F:18][C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=1[C:2]1[N:6]2[C:7]3[C:12]([N:13]=[C:14]([CH3:15])[C:5]2=[C:4]([CH3:17])[N:3]=1)=[CH:11][CH:10]=[C:9]([F:16])[CH:8]=3

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 27343342,4-Difluorophenylboronic acidHCID 577324521-Bromo-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline

생성물 1

HCID 426292321-(2,4-Difluorophenyl)-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline수율 50.1%

시약·촉매·용매 1

HCID 178418397HCID 178418397, 화합물촉매

실험 절차

Following the general Suzuki coupling procedure, reaction of bromide 5A (75 mg, 0.25 mmol), 2,4-difluorophenylboronic acid (48 mg, 0.30 mmol), K2CO3 (105 mg, 0.75 mmol) and Pd(PPh3)4 (5.8 mg, 0.005 mmol) provided the coupling product as a white powder (41 mg, 50% yield). EIMS 328.0 [M+H]+.

출처 및 근거

ORD 기록
ord-c5428db5ffa14cbd914021a161fcebfb
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875618B2

연결된 노트

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