Benzenamine, 2-chloro-4-fluoro- → 4-[(2-chloro-4-fluorophenyl)amino]-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one

HRID 254341

반응식

HRID 254341 반응식
[N:1]1([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:6][CH2:5][C:4](=O)[CH2:3][C:2]1=[O:8].[Cl:15][C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[NH2:23]>C1(C)C=CC=CC=1>[Cl:15][C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[NH:23][C:4]1[CH2:5][CH2:6][N:1]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[C:2](=[O:8])[CH:3]=1

참가 물질

4

반응물 2

HCID 75013Benzenamine, 2-chloro-4-fluoro-HCID 22038474[1,1']Bipiperidinyl-2,4-dione

생성물 1

HCID 668666694-[(2-chloro-4-fluorophenyl)amino]-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one수율 55%

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
110 °C

실험 절차

[1,1′]-Bipiperidinyl-2,4-dione (2.00 g, 10.19 mmol) was dissolved in toluene (8 ml) and 2-chloro-4-fluorophenylamine (1.78 g, 12.23 mmol) was added. More toluene (5 ml) was added. The reaction mixture was boiled under reflux at 110° C. for 17 h then allowed to cool. When the reaction mixture reached rt the product precipitated and it was collected by filtration to yield a beige solid (1.80 g, 55%).

후처리

  1. temperatureto cool
  2. customreached rt
  3. customprecipitated
  4. filtrationit was collected by filtration

출처 및 근거

ORD 기록
ord-351039c1318f482094b1d994f98819e2
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875626B2

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