Ethylenediamine → 2-(2-Fluoro-5-methyl-benzyl)-4,5-dihydro-1H-imidazole

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][C:10]#[N:11].[CH2:12](N)[CH2:13][NH2:14]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][C:10]1[NH:14][CH2:13][CH2:12][N:11]=1

참가 물질

반응물 2

HCID 3301Ethylenediamine

HCID 177506762-Fluoro-5-methylphenylacetonitrile

생성물 1

HCID 589517832-(2-Fluoro-5-methyl-benzyl)-4,5-dihydro-1H-imidazole

실험 절차

2-(2-Fluoro-5-methyl-benzyl)-4,5-dihydro-1H-imidazole was prepared from (2-fluoro-5-methyl-phenyl)-acetonitrile and ethylene diamine in analogy to Example 19 b): light yellow powder; MS (ISP): 193.0 ((M+H)+.).

출처 및 근거

ORD 기록: ord-980ccfae48f64b4ba8f89b76d5dce4b1
출처 데이터셋: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07875645B2

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