Ethylenediamine → 2-(2,6-Difluoro-3-methyl-benzyl)-4,5-dihydro-1H-imidazole

반응식

[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][C:11]#[N:12].[CH2:13](N)[CH2:14][NH2:15]>>[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][C:11]1[NH:15][CH2:14][CH2:13][N:12]=1

참가 물질

반응물 2

HCID 3301Ethylenediamine

HCID 27741582,6-Difluoro-3-Methylphenylacetonitrile

생성물 1

HCID 589518602-(2,6-Difluoro-3-methyl-benzyl)-4,5-dihydro-1H-imidazole

실험 절차

2-(2,6-Difluoro-3-methyl-benzyl)-4,5-dihydro-1H-imidazole was prepared from (2,6-difluoro-3-methyl-phenyl)-acetonitrile and ethylene diamine in analogy to Example 19 b): colourless powder; MS (ISP): 210.1 ((M+H)+.).

출처 및 근거

ORD 기록: ord-841ad183ec5344268c400db20bffe5e5
출처 데이터셋: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07875645B2

반응 노트

불러오는 중…