Ethylenediamine → Rac-2-[1-(2,3-difluoro-phenyl)-ethyl]-4,5-dihydro-1h-imidazole

HRID 254522노트

반응식

HRID 254522 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([CH3:12])[C:10]#[N:11].[CH2:13](N)[CH2:14][NH2:15]>>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([C:10]1[NH:15][CH2:14][CH2:13][N:11]=1)[CH3:12]

참가 물질

3

반응물 2

HCID 3301EthylenediamineHCID 552642322-(2,3-Difluorophenyl)propanenitrile

생성물 1

HCID 58951717Rac-2-[1-(2,3-difluoro-phenyl)-ethyl]-4,5-dihydro-1h-imidazole

실험 절차

rac-2-[1-(2,3-Difluoro-phenyl)-ethyl]-4,5-dihydro-1H-imidazole was prepared from rac-2-(2,3-difluoro-phenyl)-propionitrile and ethylene diamine in analogy to Example 19 b): off-white solid; MS (EI): 210.1 ((M+H)+.).

출처 및 근거

ORD 기록
ord-5066ef2a080b47198c53e593505d8ea6
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875645B2

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