Oxalyl chloride → Hexahydro-2,5-methano-pentalene-3a-carbonyl chloride

HRID 255050

반응식

HRID 255050 반응식
[CH2:1]1[CH:8]2[C:4]3([C:10]([OH:12])=O)[CH2:5][CH:6]([CH2:9][CH:2]1[CH2:3]3)[CH2:7]2.C(Cl)(=O)C([Cl:16])=O>ClCCl>[CH2:1]1[CH:8]2[C:4]3([C:10]([Cl:16])=[O:12])[CH2:5][CH:6]([CH2:9][CH:2]1[CH2:3]3)[CH2:7]2

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 2733865Hexahydro-2,5-methanopentalene-3a(1H)-carboxylic acid

생성물 1

HCID 13182402Hexahydro-2,5-methano-pentalene-3a-carbonyl chloride수율 99.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of commercially available hexahydro-2,5-methano-pentalene-3a-carboxylic acid (10 g, 0.06 mol) in dichloromethane (200 mL) was added oxalyl chloride (8.7 g, 0.066 mol). The mixture was stirred overnight and then concentrated under reduced pressure to afford the title compound as a colorless oil (11 g, 99%). MS (DCI/NH3) m/z 184 (M+H)+.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-82faefc782d147d88966d283fa9acab9
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875639B2

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