Benzoic acid, 3-isothiocyanato- → 3-{3-[5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzoic acid

HRID 25507

반응식

HRID 25507 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[Cl:11])[NH:7][C:6]([C:12]1[CH:13]=[CH:14][C:15]([O:19][CH3:20])=[C:16]([NH2:18])[CH:17]=1)=[CH:5]2.[C:21]([C:24]1[CH:25]=[C:26]([N:30]=[C:31]=[S:32])[CH:27]=[CH:28][CH:29]=1)([OH:23])=[O:22]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[Cl:11])[NH:7][C:6]([C:12]1[CH:13]=[CH:14][C:15]([O:19][CH3:20])=[C:16]([NH:18][C:31](=[S:32])[NH:30][C:26]3[CH:25]=[C:24]([CH:29]=[CH:28][CH:27]=3)[C:21]([OH:23])=[O:22])[CH:17]=1)=[CH:5]2

참가 물질

3

반응물 2

HCID 75046Benzoic acid, 3-isothiocyanato-HCID 98361915-(5,6-dichloro-1H-indol-2-yl)-2-methoxy-phenylamine

생성물 1

HCID 101409763-{3-[5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzoic acid

실험 절차

3-{3-[5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzoic acid was prepared from the product of Example 18, Step D, 5-(5,6-dichloro-1H-indol-2-yl)-2-methoxy-phenylamine (0.64 g, 1.72 mmol) and 3-carboxyphenyl isothiocyanate (0.359 g, 2.0 mmol) to give the product as a reddish-tan solid (0.104 g), mp 216-218° C.

출처 및 근거

ORD 기록
ord-fc2f96c8487d4e54b033454790b8d562
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858739B2

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