4-Methoxy-2-nitrobenzoic acid → 2-Amino-4-methoxybenzoic acid

HRID 255276

반응식

HRID 255276 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([N+:12]([O-])=O)[CH:4]=1>[Pd].CO>[NH2:12][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 1

HCID 2886574-Methoxy-2-nitrobenzoic acid

생성물 1

HCID 3510102-Amino-4-methoxybenzoic acid수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

4-Methoxy-2-nitrobenzoic acid (3 g, 16.4 mmol) was hydrogenated over palladium on carbon (10%, 300 mg) in methanol (80 mL) at room temperature and normal pressure for 18 hours. The reaction mixture was filtered through celite and concentrated to dryness under reduce pressure to give 2.50 g (100%) of the product as a colorless solid.

후처리

  1. filtrationThe reaction mixture was filtered through celite and
  2. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-f8f4666ef20642c2a03ae86bb6637376
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875715B2

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