Ethyl Acetoacetate → HCID 178471725, 화합물

HRID 255398

반응식

HRID 255398 반응식
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[F:10][C:11]([F:15])([F:14])[C:12]#[N:13]>CC(C)([O-])C.[K+]>[C:3]([C:2](=[C:12]([NH2:13])[C:11]([F:15])([F:14])[F:10])[C:1]([O:7][CH2:8][CH3:9])=[O:6])(=[O:4])[CH3:5]

참가 물질

4

반응물 2

HCID 8868Ethyl AcetoacetateHCID 67710Trifluoroacetonitrile

생성물 1

HCID 178471725HCID 178471725, 화합물수율 62%

시약·촉매·용매 1

HCID 23665647Potassium tert-butoxide촉매

실험 절차

To a 1 liter, four-necked flask equipped with nitrogen inlet, thermometer, and mechanical stirrer was charged 499.74 g (490 ml, 3.84 mol) of ethyl acetoacetate and 12.9 g (0.115 mol) of potassium-t-butoxide. The resulting mixture was stirred while 391 g (4.04 mol) of trifluoroaceto-nitrile was added. The reaction mixture was washed with hexane and the resulting solid was dried in vacuo affording 535 g (62%) of the enamine as a yellow solid; mp 63°-65° C.

후처리

  1. customTo a 1 liter, four-necked flask equipped with nitrogen inlet
  2. additionwas added
  3. washThe reaction mixture was washed with hexane
  4. customthe resulting solid was dried in vacuo

출처 및 근거

ORD 기록
ord-60f8f45313854275aba8a55ac21693a9
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04698093

연결된 노트

불러오는 중…