Diethyl Ether → Methoxycarbonylmethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate

HRID 255489

반응식

HRID 255489 반응식
[Cl:1][C:2]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([OH:14])=[O:13])[CH:8]=[CH:9][CH:10]=1.C[CH:24](O)[C:25]([O-:27])=[O:26].[C:29]1(C)C=CC(S(O)(=O)=O)=CC=1.CCOCC>C1C=CC=CC=1>[Cl:1][C:2]1[CH:18]=[C:17]([C:19]([F:21])([F:20])[F:22])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]([O:14][CH2:24][C:25]([O:27][CH3:29])=[O:26])=[O:13])[CH:8]=[CH:9][CH:10]=1

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 6101p-Toluenesulfonic acidHCID 91435LactateHCID 13607437{3-[2-Chloro-4-(trifluoromethyl)phenoxy]phenyl}acetic acid

생성물 1

HCID 13630152Methoxycarbonylmethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate수율 726.9%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

3.3 g of 3-(2'-chloro-4'-trifluoromethylphenoxy) phenylacetic acid and 1 g of methylglycolate were dissolved in 50 ml of benzene. Then, 0.2 g of p-toluenesulfonic acid was added to the resulting solution, followed by heating under reflux for 3 hours. After completion of the reaction, 50 ml of ether was added. The resulting reaction mixture was washed with water according to the customary method and dehydrated with anhydrous sodium sulfate, and the solvent was distillend off under reduced pressure to obtain 3.4 g of methoxycarbonylmethyl 3-(2'-chloro-4'-trifluoromethylphenoxy)phenylacetate.

후처리

  1. temperatureby heating
  2. temperatureunder reflux for 3 hours
  3. additionwas added
  4. customThe resulting reaction mixture
  5. washwas washed with water according to the customary method

출처 및 근거

ORD 기록
ord-ea1321671bf84374b811f91bf6d035e1
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04698094

연결된 노트

불러오는 중…