3,4-Dichlorobenzotrifluoride → Benzenamine, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-fluoro-

HRID 255603

반응식

HRID 255603 반응식
[F:1][C:2]1[CH:8]=[C:7]([OH:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[OH-].[K+].Cl[C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=1[Cl:23]>CS(C)=O.O.ClCCl>[F:1][C:2]1[CH:8]=[C:7]([O:9][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=2[Cl:23])[CH:6]=[CH:5][C:3]=1[NH2:4]

참가 물질

7

반응물 3

HCID 94813,4-DichlorobenzotrifluorideHCID 14797Potassium HydroxideHCID 27359194-Amino-3-fluorophenol

생성물 1

HCID 15595105Benzenamine, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-fluoro-수율 23.2%

시약·촉매·용매 3

HCID 679Dimethyl Sulfoxide용매2회HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

A solution of 2-fluoro-4-hydroxyaniline (7.1 g) and potassium hydroxide (3.7 g, 85% pure) in dimethylsulphoxide (25 ml) was heated to 80° C. and treated with a solution of 1,2-dichloro-4-(trifluoromethyl)benzene (10.9 g) in dimethylsulphoxide (10 ml). The mixture was stirred at 90°-95° C. for 20 hours, after which time it was diluted with a mixture of water and dichloromethane. The organic phase was dried over sodium sulphate and evaporated down to give 3.6 g of the crude desired product as a brown oil.

후처리

  1. dry with materialThe organic phase was dried over sodium sulphate
  2. customevaporated down

출처 및 근거

ORD 기록
ord-d7af3625cf0c47f68044d35b3327ff7a
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04698365

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