Phosphorus oxychloride → HCID 20184101, 화합물

HRID 255700노트

반응식

[CH3:1][N:2]([CH3:31])[CH2:3][CH2:4][CH2:5][N:6]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:7]1[C:12]([NH:13][C:14](=O)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])=[CH:11][CH:10]=[CH:9][N:8]=1.P(Cl)(Cl)([Cl:34])=O>>[ClH:34].[CH3:1][N:2]([CH3:31])[CH2:3][CH2:4][CH2:5][N:6]1[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])=[N:13][C:12]2[CH:11]=[CH:10][CH:9]=[N:8][C:7]1=2

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 13986493HCID 13986493, 화합물

생성물 1

HCID 20184101HCID 20184101, 화합물

실험 절차

Following the procedure of Example 51, N-[2-[[3-(dimethylamino)propyl]phenylamino]-3-pyridinyl]-2-nitrobenzamide was cyclized to the free base of title compound with phosphorus oxychloride and thereafter converted to the hydrochloride by reacting with ethereal hydrogen chloride. Recrystallization from isopropyl alcohol, the yellow solid melted at 239°240° C.

출처 및 근거

ORD 기록: ord-050b83e8ccc645c68cc89a2353c38786
출처 데이터셋: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04698430

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