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Dimethylformamide → 7-[2-(2-formamidothiazol-4-yl)-2-cyanomethoxyiminoacetamido]-3-(1-n-hexyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid

HRID 255773
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HRID 255773 반응식
[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:13][O:14][CH2:15][C:16](=O)[NH2:17])[C:10]([OH:12])=O)[N:8]=1)=[O:2].CN(C)C=O.P(Cl)(Cl)(Cl)=O.[NH2:29][CH:30]1[C:53](=[O:54])[N:32]2[C:33]([C:50]([OH:52])=[O:51])=[C:34]([CH2:37][S:38][C:39]3[N:43]([CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])[N:42]=[N:41][N:40]=3)[CH2:35][S:36][C@H:31]12>O1CCCC1.CC(C)=O>[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:13][O:14][CH2:15][C:16]#[N:17])[C:10]([NH:29][CH:30]2[C:53](=[O:54])[N:32]3[C:33]([C:50]([OH:52])=[O:51])=[C:34]([CH2:37][S:38][C:39]4[N:43]([CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH3:49])[N:42]=[N:41][N:40]=4)[CH2:35][S:36][C@H:31]23)=[O:12])[N:8]=1)=[O:2]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 538052302-(2-Formamidothiazol-4-yl)-2-carbamoylmethoxyiminoacetic acidHCID 704323317-amino-3-(1-hexyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid

생성물 1

HCID 1317153017-[2-(2-formamidothiazol-4-yl)-2-cyanomethoxyiminoacetamido]-3-(1-n-hexyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid
수율 38.6%

시약·촉매·용매 2

HCID 180Acetone용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2-(2-formamidothiazol-4-yl)-2-carbamoylmethoxyiminoacetic acid (syn isomer, 1.35 g.), N,N-dimethylformamide (0.814 g.) and phosphoryl chloride (1.71 g.) in tetrahydrofuran (13.4 ml.) and a solution of 7-amino-3-(1-n-hexyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (1.95 g.) in 50% aqueous acetone (20 ml.) were treated in a similar manner to that of Example 9-(1) to give 7-[2-(2-formamidothiazol-4-yl)-2-cyanomethoxyiminoacetamido]-3-(1-n-hexyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 1.2 g.).

출처 및 근거

ORD 기록
ord-fb2ffc85d74741899de2c0eb88226271
출처 데이터셋
uspto-grants-1987_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04698337

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