Diethyl Oxalate → HCID 20165027, 화합물

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[CH2:1]([NH:4][CH2:5][CH2:6][NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=1)[C:2]#[CH:3].C(O[C:21](=[O:27])[C:22]([O:24]CC)=O)C>>[CH2:1]([N:4]1[CH2:5][CH2:6][N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:16])[F:17])[CH:9]=2)[C:21](=[O:27])[C:22]1=[O:24])[C:2]#[CH:3]

참가 물질

반응물 2

HCID 7268Diethyl Oxalate

HCID 20165017HCID 20165017, 화합물

생성물 1

HCID 20165027HCID 20165027, 화합물

실험 절차

Condensation of N-propargyl-N'-(3-trifluoromethyl-phenyl)-ethylenediamine, obtainable according to 3.2, with diethyloxalate gave 1-propargyl-4-(3-trifluoromethyl-phenyl)-piperazin-2,3-dione. This compound was reduced to the title compound with lithium aluminum hydride or borane and was processed according to Example 5. White crystals, melting point 218°-219° C. (decomposition).

출처 및 근거

ORD 기록: ord-ff3ed90bcccf499da590d53af85454a2
출처 데이터셋: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04699910

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