Dimethylformamide → 3-(2-Methyl-thiazol-4-yl)-phenylamine

HRID 255900

반응식

HRID 255900 반응식
Br.[NH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6](=O)[CH2:7]Br.[C:13]([NH2:16])(=[S:15])[CH3:14].CN(C)C=O.[OH-].[Na+]>O>[CH3:14][C:13]1[S:15][CH:7]=[C:6]([C:5]2[CH:10]=[CH:11][CH:12]=[C:3]([NH2:2])[CH:4]=2)[N:16]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 14798Sodium HydroxideHCID 2723949ThioacetamideHCID 201651043-Amino-phenacyl bromide hydrobromide

생성물 1

HCID 7365353-(2-Methyl-thiazol-4-yl)-phenylamine수율 79%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3-amino-phenacyl bromide hydrobromide (11.78 g), thioacetamide (3 g) and dimethylformamide (20 ml) was stirred at room temperature for 24 hours and then poured into water (100 ml). The resulting solution was made alkaline with 10% sodium hydroxide, and the precipitate was filtered off and dried to give 6 g of 2-methyl-4-(3-amino-phenyl)-thiazole; M.p. 134°-137° C.

후처리

  1. filtrationthe precipitate was filtered off
  2. customdried

출처 및 근거

ORD 기록
ord-6884dac1deb44f1293e4f4875b0ec887
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04699915

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