Sodium Hydroxide → alpha-[6-(1-Carboxy-3-phenylpropylamino)-2-(2-naphthyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetic acid

HRID 256051노트

반응식

C([O:3][C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[CH:32]=[CH:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:24]=2)[CH2:19][N:18]([CH2:33][C:34]([OH:36])=[O:35])[C:17]1=[O:37])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])C.[OH-].[Na+]>>[C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[CH:32]=[CH:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:24]=2)[CH2:19][N:18]([CH2:33][C:34]([OH:36])=[O:35])[C:17]1=[O:37])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([OH:5])=[O:3]

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 20164862HCID 20164862, 화합물

생성물 1

HCID 20164820alpha-[6-(1-Carboxy-3-phenylpropylamino)-2-(2-naphthyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetic acid수율 70.3%

실험 절차

200 mg of α-[6-(1-ethoxycarbonyl-3-phenylpropylamino)-2-(2-naphthyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetic acid (prepared as described in Example 40 above) were hydrolyzed with aqueous sodium hydroxide in the same manner as described in Example 38, to give 133 mg of the title compound as a powder.

출처 및 근거

ORD 기록: ord-1a777d6804814597b52bd7a66fe6ed92
출처 데이터셋: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04699905

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