Hydrochloric Acid → 3,3-Dimethyl-5-oxopentanoic acid

HRID 256217노트

반응식

HRID 256217 반응식
[CH3:1][C:2]([CH3:12])([CH2:9][CH:10]=[O:11])[CH2:3][C:4]([O:6]CC)=[O:5].[OH-].[K+].Cl>CO.O>[CH3:1][C:2]([CH3:12])([CH2:9][CH:10]=[O:11])[CH2:3][C:4]([OH:6])=[O:5]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13050815Ethyl 4-formyl-3,3-dimethylbutanoate

생성물 1

HCID 30187243,3-Dimethyl-5-oxopentanoic acid수율 83.6%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

To a solution of 1.50 g (8.71 mmol) of ethyl 3,3-dimethyl-5-oxopentanoate in 50 mL of methanol and 1 mL of water was added 1.0 g (17.8 mmol) of potassium hydroxide. The reaction mixture was stirred at room temperature for 411/2 hours. The reaction mixture was diluted with water and then made acidic by the addition of aqueous hydrochloric acid. The resulting solution was extracted with methylene chloride repeatedly. The combined organic layer was washed with an aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. Removal of the solvent afforded 1.05 g of 3,3-dimethyl-5-oxopentanoic acid, 84% crude yield. The nmr spectrum was consistent with the proposed structure.

후처리

  1. extractionThe resulting solution was extracted with methylene chloride repeatedly
  2. washThe combined organic layer was washed with an aqueous solution of sodium chloride
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-cf6c7929ca4a43679bb6ac9d7ece8b45
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701539

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