Dimethyl-1,3,5-triazin-2-amine → Methyl 3-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate

HRID 256267

반응식

HRID 256267 반응식
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][O:11][C:12]([C:14]1[S:15][CH:16]=[CH:17][C:18]=1[S:19]([N:22]=[C:23]=[O:24])(=[O:21])=[O:20])=[O:13]>C(Cl)Cl>[CH3:9][C:4]1[N:5]=[C:6]([CH3:8])[N:7]=[C:2]([NH:1][C:23]([NH:22][S:19]([C:18]2[CH:17]=[CH:16][S:15][C:14]=2[C:12]([O:11][CH3:10])=[O:13])(=[O:20])=[O:21])=[O:24])[N:3]=1

참가 물질

4

반응물 2

HCID 15820Dimethyl-1,3,5-triazin-2-amineHCID 1572962-Thiophenecarboxylic acid, 3-(isocyanatosulfonyl)-, methyl ester

생성물 1

HCID 13390216Methyl 3-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate수율 62.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 1.23 g of 2-amino-4,6-dimethyl-1,3,5-triazine in 30 ml of anhydrous methylene chloride was added with stirring 2.7 g of 2-methoxycarbonyl-3-thiophenesulfonylisocyanate. The mixture was heated to the boiling point and allowed to cool and stir at ambient temperature for sixteen hours. The solid thus obtained was removed by filtration to yield 2.3 g of the crude desired product melting at 158°-178°. The product showed peaks at 1720 and 1710 cm-1, by infrared absorption spectroscopy, consistent for the desired product.

후처리

  1. temperatureThe mixture was heated to the boiling point
  2. temperatureto cool
  3. customThe solid thus obtained
  4. customwas removed by filtration

출처 및 근거

ORD 기록
ord-776621e367ab46469ce4d578bdd322a8
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04701535

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