BzMePhe → N-Methylphenylalanine
반응식
[C:1]([N:9](C)[C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(C1C=CC=CC=1)=O.[H][H]>C(O)(=O)C.Cl.[C].[Pd]>[NH:9]([CH3:1])[C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1참가 물질
6
실험 절차
A 12.66 g portion of the BzMePhe was dissolved in 120 ml of acetic acid and 47 ml of HCl, and the solution was subjected to hydrogen catalytic reduction (room temperature, 8 hours) with addition of 5.0 g of 10% palladium-carbon catalyst. After separating off the catalyst by filtration, the filtrate was concentrated in vacuo, and the concentrate was recrystallized from ethanol (50 ml)-ether (500 ml) to give 7.93 g of MePhe, yeild 94.1%. M.p. 225° C.
후처리
- customAfter separating off the catalyst
- filtrationby filtration
- concentrationthe filtrate was concentrated in vacuo
- customthe concentrate was recrystallized from ethanol (50 ml)-ether (500 ml)
출처 및 근거
- ORD 기록
- ord-b8df4400caf34844b679501083c4753f
- 출처 데이터셋
- uspto-grants-1987_10
- 특허 번호
- USRE032534
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