Ethyl 2-(2-formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetate → 2-(2-Formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetic acid

반응식

[CH:1]([NH:3][C:4]1[S:5][C:6]([Br:18])=[C:7]([C:9](=[N:15][O:16][CH3:17])[C:10]([O:12]CC)=[O:11])[N:8]=1)=[O:2]>[OH-].[Na+]>[CH:1]([NH:3][C:4]1[S:5][C:6]([Br:18])=[C:7]([C:9](=[N:15][O:16][CH3:17])[C:10]([OH:12])=[O:11])[N:8]=1)=[O:2]

참가 물질

실험 절차

1N-Aqueous sodium hydroxide (290 ml.) was added dropwise to an aqueous suspension (325 ml.) of ethyl 2-(2-formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetate (syn isomer, 32.5 g.) under ice-cooling, and the mixture was treated in a similar manner to that of Preparation 2-(2) to give 2-(2-formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetic acid (syn isomer, 21.9 g.), m.p. 165° to 167° C.

후처리

temperaturecooling
additionthe mixture was treated in a similar manner to that
customof Preparation 2-(2)

출처 및 근거

ORD 기록: ord-7c0361784a5e45438929994e6df34a92
출처 데이터셋: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04703046

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참가 물질

반응물 1

HCID 53894989Ethyl 2-(2-formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetate

생성물 1

HCID 538011022-(2-Formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetic acid수율 73.5%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

후처리

temperaturecooling
additionthe mixture was treated in a similar manner to that
customof Preparation 2-(2)

출처 및 근거

ORD 기록: ord-7c0361784a5e45438929994e6df34a92
출처 데이터셋: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04703046

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