Hydrochloric Acid → HCID 178502764, 화합물

HRID 256435노트

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HRID 256435 반응식
C([NH:3][C:4]1[S:5][C:6]([Br:36])=[C:7]([C:9](=[N:33][O:34][CH3:35])[C:10]([NH:12][CH:13]2[C:31](=[O:32])[N:15]3[C:16]([C:28]([OH:30])=[O:29])=[C:17]([CH:20]([S:22][C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH3:21])[CH2:18][S:19][C@H:14]23)=[O:11])[N:8]=1)=O.[ClH:37]>>[ClH:37].[NH2:3][C:4]1[S:5][C:6]([Br:36])=[C:7]([C:9](=[N:33][O:34][CH3:35])[C:10]([NH:12][CH:13]2[C:31](=[O:32])[N:15]3[C:16]([C:28]([OH:30])=[O:29])=[C:17]([CH:20]([S:22][C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH3:21])[CH2:18][S:19][C@H:14]23)=[O:11])[N:8]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 1785027637-[2-(2-formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid

생성물 1

HCID 178502764HCID 178502764, 화합물

실험 절차

7-[2-(2-Formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer, 700 mg.) was treated with conc. hydrochloric acid (1 ml.) in a similar manner to that of Example 1-(2) to give 7-[2-(2-amino-5-bromothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid hydrochloride (syn isomer, 660 mg.).

출처 및 근거

ORD 기록
ord-a08806332f4641c9999664deeeb40b22
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04703046

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