Monobasic potassium phosphate → Ribavirin

HRID 256512

반응식

HRID 256512 반응식
[NH:1]1C=CN=N1.[C@@H:6]1([N:15]2C3N=C[N:21]=[C:19]([OH:20])[C:18]=3[N:17]=[CH:16]2)[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[C@H:7]1[OH:8].P([O-])(O)(O)=O.[K+]>>[CH:16]1[N:15]([C@@H:6]2[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[C@H:7]2[OH:8])[N:1]=[C:18]([C:19]([NH2:21])=[O:20])[N:17]=1

참가 물질

4

반응물 3

HCID 516951Monobasic potassium phosphateHCID 178418936HCID 178418936, 화합물HCID 178521066(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol

생성물 1

HCID 37542Ribavirin

실험 절차

By using a substrate solution (pH 6.0) containing 40 mM triazole as the base donor, 60 mM inosine as the saccharide residue donor and 40 mM potassium dihydrogenphosphate, reactions were carried out in the same manner as in Example 1 at respective reaction temperature (40° to 70° C.) for 24 hours to produce ribavirin. The results are shown in Table 8.

출처 및 근거

ORD 기록
ord-ad34d5e319f442798901411e2fa06cde
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05258301

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