Water → 3-(3-(3-Pentynyloxy)-1,2,5-thiadiazol-4-yl)pyridine

HRID 256953

반응식

HRID 256953 반응식
[CH2:1]([OH:6])[CH2:2][C:3]#[C:4][CH3:5].[H-].[Na+].Cl[C:10]1[C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:12][S:13][N:14]=1.O>O1CCCC1>[CH2:1]([O:6][C:10]1[C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[N:12][S:13][N:14]=1)[CH2:2][C:3]#[C:4][CH3:5]

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 662953-Pentyn-1-olHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

생성물 1

HCID 190752603-(3-(3-Pentynyloxy)-1,2,5-thiadiazol-4-yl)pyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 3-pentyn-1-ol (750 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

후처리

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether phase was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-155419b9b0ac400fbd6ca017b2484a4e
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05260311

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