Water → 3-(3-(5-Hexenyloxy)-1,2,5-thiadiazol-4-yl)pyridine
반응식
[CH2:1]([OH:7])[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6].[H-].[Na+].Cl[C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1.O>O1CCCC1>[CH2:1]([O:7][C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1)[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6]참가 물질
6
실험 절차
To a solution of 5-hexen-1-ol (900 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
후처리
- extractionthe mixture was extracted with ether
- dry with materialThe ether phase was dried
- customevaporated
출처 및 근거
- ORD 기록
- ord-de2db69a59f3442298824da9564c774f
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05260311
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