1-(4-methoxyphenyl)-N-methylmethanamine → 4-(N-(4-methoxybenzyl)-N-methylamino)-1-(4-nitrophenyl)piperidine

HRID 257094

반응식

HRID 257094 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:17][O:18][C:19]1[CH:27]=[CH:26][C:22]([CH2:23][NH:24][CH3:25])=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:27]=[CH:26][C:22]([CH2:23][N:24]([CH:13]2[CH2:14][CH2:15][N:10]([C:7]3[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[CH2:11][CH2:12]2)[CH3:25])=[CH:21][CH:20]=1

참가 물질

3

반응물 2

HCID 4854071-(4-methoxyphenyl)-N-methylmethanamineHCID 38425621-(4-Nitrophenyl)piperidin-4-one

생성물 1

HCID 197843544-(N-(4-methoxybenzyl)-N-methylamino)-1-(4-nitrophenyl)piperidine수율 72.4%

실험 절차

3.0 g (13.6 mmol) of 1-(4-nitrophenyl)-4-piperidone and 2.0 g (13.6 mmol) of N-(4-methoxybenzyl)-N-methylamine were reacted in a similar manner to Example 1. 3.5 g of 4-(N-(4-methoxybenzyl)-N-methylamino)-1-(4-nitrophenyl)piperidine were obtained. Melting point 144°-145° C.

출처 및 근거

ORD 기록
ord-7f9b91675af14320a1c9c71b9336bdf2
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05260318

연결된 노트

불러오는 중…