2-Fluorobenzoyl chloride → 2-(2-fluorobenzoyl)-N-methyl-1-hydrazinecarbothioamide
반응식
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](Cl)=[O:11]>C(Cl)(Cl)Cl>[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([NH:5][NH:4][C:3]([NH:2][CH3:1])=[S:6])=[O:11]참가 물질
4
실험 절차
To a stirred room temperature suspension of 4-methylthiosemicarbazide (7.9 g, 7.5×10-2 mole) and CHCl3 (190 ml), 2-fluorobenzoyl chloride (9.4 ml, 7.9×10-2 mole) was added dropwise. After stirring overnight at room temperature, the precipitate was collected by filtration and the product was washed with two portions of Et2O. Drying by suction gave a colorless powder which was used without further purification in the subsequent cyclization step.
후처리
- additionwas added dropwise
- filtrationthe precipitate was collected by filtration
- washthe product was washed with two portions of Et2O
- customDrying by suction
- customgave a colorless powder which
- customwas used without further purification in the subsequent cyclization step
출처 및 근거
- ORD 기록
- ord-e1f11bf6f284453ba0fdc53a0a70ee9c
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05260450
반응 노트
불러오는 중…