2-(Methylamino)ethanol → 2-(Methyl(2-hydroxyethyl)amino)benzothiazole

HRID 257169

반응식

HRID 257169 반응식
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:11][NH:12][CH2:13][CH2:14][OH:15]>O>[CH3:11][N:12]([CH2:13][CH2:14][OH:15])[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1

참가 물질

4

반응물 2

HCID 80162-(Methylamino)ethanolHCID 119872-Chlorobenzothiazole

생성물 1

HCID 6008992-(Methyl(2-hydroxyethyl)amino)benzothiazole

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

A mixture of 2-chlorobenzothiazole (8.5 g) and 2-methylaminoethanol (20 ml) was heated at 120° C. under pressure in a sealed, glass lined, stainless steel reaction vessel for 18 hours. After cooling, the oil was added to water (100 ml), extracted with dichloromethane (2×100 ml), the organic extracts were dried (MgSO4), filtered and evaporated to dryness. Chromatography of the residual oil on silica-gel in 21/2% methanol in dichloromethane gave the title compound which was used in Preparation 1 without further purification.

후처리

  1. temperatureAfter cooling
  2. extractionextracted with dichloromethane (2×100 ml)
  3. dry with materialthe organic extracts were dried (MgSO4)
  4. filtrationfiltered
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-6d84f11f982a47ae8240ea0f0041acd5
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05260445

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