Bromine → 7-Bromo-5-chloro-2,3-dihydrobenzofuran

HRID 257516

반응식

HRID 257516 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[Br:11]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([Br:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

참가 물질

5

반응물 3

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 5929645-Chloro-2,3-dihydro-1-benzofuran

생성물 1

HCID 197834187-Bromo-5-chloro-2,3-dihydrobenzofuran수율 92%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

To a stirred solution of (33) (1.84 g, 11.93 mmol) in acetic acid (10 ml) at 0° C., was slowly added a solution of bromine (1.24 ml, 24 mmol) in acetic acid (5 ml). The reaction mixture was stirred at room temperature for 4.5 h. A 10% sodium thiosulphate solution (70 ml) was added and the mixture stirred for 10 min. The bulk of the solvent was evaporated in vacuo. The resulting oil was dissolved in ether (50 ml), washed with water (20 ml), saturated NaHCO2 (2×15 ml), brine (1×15 ml), dried Na2SO4 and evaporated in vacuo to give 2.55 g (92%) of (34) as a oil.

후처리

  1. stirringthe mixture stirred for 10 min
  2. customThe bulk of the solvent was evaporated in vacuo
  3. dissolutionThe resulting oil was dissolved in ether (50 ml)
  4. washwashed with water (20 ml), saturated NaHCO2 (2×15 ml), brine (1×15 ml), dried Na2SO4
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-f2c2ef8aac97430eba3688d429ad02ec
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262430

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