Sodium Hydroxide → 2-[4-[2-(4,5-Diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid

HRID 257622노트

반응식

HRID 257622 반응식
[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][C:20]3[CH:31]=[CH:30][C:23]([O:24][CH2:25][C:26]([O:28]C)=[O:27])=[CH:22][CH:21]=3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][C:20]3[CH:21]=[CH:22][C:23]([O:24][CH2:25][C:26]([OH:28])=[O:27])=[CH:30][CH:31]=3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19783610Methyl 2-[4-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetate

생성물 1

HCID 103635422-[4-[2-(4,5-Diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid수율 59.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of methyl 2-[4-[2-(4,5-diphenyl-2oxazolyl]ethyl]phenoxy]acetate (5 g, 12 mmold), 5N sodium hydroxide solution (7.26 mL) and methanol (100 mL) was heated on a steam bath for 45 minutes. The solution was concentrated in vacuo diluted with water and 2N HCl solution an a white solid filtered off. Recrystallization from methanol gave 2-[4-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid (2.88 g, 59%), m.p. 147°-149° C.

후처리

  1. temperaturewas heated on a steam bath for 45 minutes
  2. concentrationThe solution was concentrated in vacuo
  3. additiondiluted with water and 2N HCl solution an a white solid
  4. filtrationfiltered off
  5. customRecrystallization from methanol

출처 및 근거

ORD 기록
ord-5fea2c70e7f04a8c87579f8fcd6406c6
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262540

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