Dimethyldioxirane → 1-Hydroxy-2,6-diphenyl-3-methylpiperidin-4-yl Laurate

HRID 257678

반응식

HRID 257678 반응식
[C:1]([O:14][CH:15]1[CH2:20][CH:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[NH:18][CH:17]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:16]1[CH3:33])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].CC1(C)O[O:36]1>>[C:1]([O:14][CH:15]1[CH2:20][CH:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:18]([OH:36])[CH:17]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:16]1[CH3:33])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

3

반응물 2

HCID 115197DimethyldioxiraneHCID 540525282,6-Diphenyl-3-methylpiperidin-4-yl Laurate

생성물 1

HCID 545511061-Hydroxy-2,6-diphenyl-3-methylpiperidin-4-yl Laurate수율 99.4%

실험 절차

The general procedure of Example 2 is repeated using 11.5 g (25.5 mmol) of 2,6-diphenyl-3-methylpiperidin-4-yl laurate and 570 mL (25.5 mmol) of dimethyldioxirane (0.045M in acetone). 11.8 g (99% yield) of the title compound is isolated: mp 84°-91° C.

출처 및 근거

ORD 기록
ord-bd28bc9a3f394ae3a460136e6323746f
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262538

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