Hydrochloric Acid → 4-Methoxymethyl-2-nitrobenzoic acid
반응식
Cl[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1.[CH3:16][O-:17].[Na+].CO.O.Cl>CO>[CH3:16][O:17][CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([OH:9])=[O:8])=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1참가 물질
6
실험 절차
A mixture of methyl 4-chloromethyl-2-nitrobenzoate (1.6 g), 28% sodium methoxide-methanol solution (2.5 ml) in methanol [16 ml) was stirred under reflux for 24 hours. To this mixture, water (5 ml) was added and the mixture was stirred for 2 hours, acidified with 1N hydrochloric acid, extracted with ethyl acetate. The combined organic extract was washed with water, dried over magnesium sulfate and evaporated to give 4-methoxymethyl-2-nitrobenzoic acid (0.84 g).
후처리
- temperatureunder reflux for 24 hours
- stirringthe mixture was stirred for 2 hours
- extractionextracted with ethyl acetate
- extractionThe combined organic extract
- washwas washed with water
- dry with materialdried over magnesium sulfate
- customevaporated
출처 및 근거
- ORD 기록
- ord-9ea8fbbe8e9b4a37882edb478ff0deef
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05264438
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