(2-Bromoethyl)cyclohexane → 4-{1-[(2E)-but-2-en-1-yloxy]ethyl}-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline

HRID 25787

반응식

HRID 25787 반응식
C(OC(N1C2C(=CC(C3C=CC=CC=3OC)=CC=2)C(C(O)C)=CC1(C)C)=O)(C)(C)C.[CH:31]1([CH2:37][CH2:38][O:39][CH:40]([C:42]2[C:51]3[C:46](=[CH:47][CH:48]=[C:49]([C:52]4[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=4[O:58][CH3:59])[CH:50]=3)[NH:45][C:44]([CH3:61])([CH3:60])[CH:43]=2)[CH3:41])CCCC[CH2:32]1.C[Si]([N-][Si](C)(C)C)(C)C.[Na+].C1(CCBr)CCCCC1>C1COCC1>[CH2:38]([O:39][CH:40]([C:42]1[C:51]2[C:46](=[CH:47][CH:48]=[C:49]([C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][C:53]=3[O:58][CH3:59])[CH:50]=2)[NH:45][C:44]([CH3:61])([CH3:60])[CH:43]=1)[CH3:41])/[CH:37]=[CH:31]/[CH3:32]

참가 물질

5

반응물 3

HCID 15440(2-Bromoethyl)cyclohexaneHCID 2724254Sodium bis(trimethylsilyl)amideHCID 691539464-[1-(2-Cyclohexylethoxy)ethyl]-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline 4-(1-Hydroxyethyl)-6-(2-methoxyphenyl)-2,2-dimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester

생성물 1

HCID 103166704-{1-[(2E)-but-2-en-1-yloxy]ethyl}-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline수율 101%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-[1-(2-Cyclohexylethoxy)ethyl]-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline 4-(1-Hydroxyethyl)-6-(2-methoxyphenyl)-2,2-dimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester (70 mg) was treated with 255 μL of 1 M solution of sodium bis(trimethylsilyl)amide in THF and 49 mg of 2-cyclohexylethyl bromide to give the alkylated product, which was deprotected to yield 31 mg of title compound as an oil.

후처리

  1. customto give the alkylated product, which

출처 및 근거

ORD 기록
ord-ce9a7ee077a34850b30661c174215de3
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858627B2

연결된 노트

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