Water → 3-(3-(2-Butoxyethoxy)-1,2,5-thiadiazol-4-yl)pyridine
반응식
[CH2:1]([O:5][CH2:6][CH2:7][OH:8])[CH2:2][CH2:3][CH3:4].[H-].[Na+].Cl[C:12]1[C:13]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[N:14][S:15][N:16]=1.O>O1CCCC1>[CH2:1]([O:5][CH2:6][CH2:7][O:8][C:12]1[C:13]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[N:14][S:15][N:16]=1)[CH2:2][CH2:3][CH3:4]참가 물질
6
실험 절차
To a solution of 2-butoxyethanol (1.06 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
후처리
- extractionthe mixture was extracted with ether
- dry with materialThe ether phase was dried
- customevaporated
출처 및 근거
- ORD 기록
- ord-4955c24b872b4410ac7d89aef338fb6c
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05264444
반응 노트
불러오는 중…