Hydroxyamine hydrochloride → alpha-Oximino-3-pyridylacetamidoxime
반응식
[N:1](=[C:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4]#[N:5])[OH:2].Cl.[NH2:13][OH:14].C([O-])(=O)C.[Na+]>C(O)C>[N:1](=[C:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4](=[N:13][OH:14])[NH2:5])[OH:2]참가 물질
5
실험 절차
A mixture of alpha-oximino-3-pyridylacetonitrile (41.0 g, 279 mmol), hydroxylamine hydrochloride (21.5 g, 310 mmol) and sodium acetate (50.8 g, 620 mmol) in ethanol (99.9%, 500 ml) was refluxed for 4 h. After cooling, the precipitate was collected by filtration and dried. The precipitate contained the wanted product and sodium acetate (85 g, 168%); M+ : 180.
후처리
- temperaturewas refluxed for 4 h
- temperatureAfter cooling
- filtrationthe precipitate was collected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-7fd52ef1078448cbb7c09567feff6bef
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05264444
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