Acetic Acid → 4-(2-Methylphenyl)-2-oxo-2,6,7,8-tetrahydrocyclopenta[g][1]benzopyran-3-carboxylic acid

HRID 258040노트

반응식

HRID 258040 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:13]2[CH:14]=[C:15]3[CH2:20][CH2:19][CH2:18][C:16]3=[CH:17][C:12]=2[O:11][C:10](=[O:21])[C:9]=1[C:22]([O:24]CC)=[O:23].Cl.C(O)(=O)C>O>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:13]2[CH:14]=[C:15]3[CH2:20][CH2:19][CH2:18][C:16]3=[CH:17][C:12]=2[O:11][C:10](=[O:21])[C:9]=1[C:22]([OH:24])=[O:23]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 10450416HCID 10450416, 화합물

생성물 1

HCID 103586304-(2-Methylphenyl)-2-oxo-2,6,7,8-tetrahydrocyclopenta[g][1]benzopyran-3-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of ethyl 4-(2-methylphenyl)-2-oxo-2,6,7,8-tetrahydrocyclopenta[g][1]benzopyran-3-carboxylate (5.0 g), concentrated hydrochloric acid (13 ml) and acetic acid (25 ml) was refluxed for 12 hours. To this reaction mixture was added water, whereupon 4-(2-methylphenyl)-2-oxo-2,6,7,8-tetrahydrocyclopenta[g][1]benzopyran-3-carboxylic acid was obtained as crystals (4.5 g, 97.8%). Recrystallization from acetone-hexane gave colorless prisms, mp 213°-214° C.

후처리

  1. temperaturewas refluxed for 12 hours

출처 및 근거

ORD 기록
ord-25b501845b9d4c5cbd894ff881b46bbe
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05264454

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