Diethyl Ether → Ethyl 2-(acetylthiomethyl)butanoate

HRID 258484

반응식

HRID 258484 반응식
[CH2:1]([C:3](=[CH2:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].[S:10]1C=CC=C1CC(O)=O.[CH3:19][CH2:20][O:21]CC>>[C:20]([S:10][CH2:9][CH:3]([CH2:1][CH3:2])[C:4]([O:6][CH2:7][CH3:8])=[O:5])(=[O:21])[CH3:19]

참가 물질

4

반응물 3

HCID 3283Diethyl EtherHCID 159702-Thiopheneacetic acidHCID 291416Ethyl 2-methylidenebutanoate

생성물 1

HCID 15025921Ethyl 2-(acetylthiomethyl)butanoate

반응 조건

온도
65 °C

실험 절차

Ethyl 2-ethylpropenoate (5 g, 39 mmol) was diluted with 5.6 mL (78 mmol) of thiolacetic acid and stirred at 65° C. for 36 h. The mixture was then diluted with ether, washed with water and the organic phase was dried with Na2SO4. Evaporation to dryness yielded the title material as an orange oil which was used as such for the next step.

후처리

  1. washwashed with water
  2. dry with materialthe organic phase was dried with Na2SO4
  3. customEvaporation to dryness

출처 및 근거

ORD 기록
ord-ddda9115889046ae9570164ebc99bd6f
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05266568

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