Sodium Hydroxide → 2-nitromethylenetetrahydro-2H-1,3-thiazine

HRID 258550

반응식

HRID 258550 반응식
[N+:1]([C:4](=[C:10]1[NH:15][CH2:14][CH2:13][CH2:12][S:11]1)C(OCC)=O)([O-:3])=[O:2].[OH-].[Na+]>C(O)(=O)C>[N+:1]([CH:4]=[C:10]1[NH:15][CH2:14][CH2:13][CH2:12][S:11]1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 71443329Ethyl nitro(1,3-thiazinan-2-ylidene)acetate

생성물 1

HCID 428532-nitromethylenetetrahydro-2H-1,3-thiazine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2.3 g of 1A was added to 10 ml of 20% aqueous sodium hydroxide and the mixture was stirred at room temperature for 12 hours. The resulting solution was treated dropwise with 3.5 g of acetic acid. The addition was accompanied by vigorous gas evolution. The resulting mixture was extracted with methylene chloride and the extract was dried (magnesium sulfate) and concentrated under reduced pressure to give tetrahydro-2-(nitromethylene)-2H-1,3-thiazine (1B) as a pale yellow solid, m.p. 76°-78°.

후처리

  1. additionThe addition
  2. extractionThe resulting mixture was extracted with methylene chloride
  3. dry with materialthe extract was dried (magnesium sulfate)
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ecbbf5c76427496194d2c544b27b633b
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04033952

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