Dichloromethane → 1~2~,2~2~:2~3~,3~2~-Terpyridine

반응식

Cl.[C:2](Cl)(=O)[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1.CC[N:13]([CH:17]([CH3:19])C)[CH:14]([CH3:16])C.CO[C:22]1[CH:27]=CC=[C:24]([NH2:28])[CH:23]=1.[CH2:29](Cl)Cl>>[N:13]1[CH:14]=[CH:16][CH:29]=[CH:19][C:17]=1[C:4]1[C:3]([C:2]2[CH:27]=[CH:22][CH:23]=[CH:24][N:28]=2)=[CH:8][CH:7]=[CH:6][N:5]=1

참가 물질

반응물 4

HCID 6344Dichloromethane

HCID 108243-Methoxyaniline

HCID 81531Diisopropylethylamine

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

생성물 1

HCID 149389711~2~,2~2~:2~3~,3~2~-Terpyridine

실험 절차

Nicotinoyl chloride hydrochloride (0.3 g, 1.685 mmol), DIEA (0.65 g, 5.06 mmol, 3.0 eqv), and ortho- or meta-anisidine (0.21 g, 1.68 mmol, 1 eqv) were dissolved in CH2Cl2 and stirred at rt for 48 h. The solution was extracted with 1N HCl solution. The aqueous layer was neutralized with a NaHCO3 solution and extracted with CH2Cl2. The organic extracts were combined, dried (MgSO4), filtered, and concentrated in vacuo to give a white solid.