Methanol → p-Chloro-o-toluidine hydrochloride

HRID 258634

반응식

HRID 258634 반응식
[Cl:1]Cl.C([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:12])=O.CO>C(Cl)(Cl)Cl>[ClH:1].[NH2:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:1])=[CH:8][C:7]=1[CH3:12]

참가 물질

5

반응물 3

HCID 887MethanolHCID 7202Formamide, N-(2-methylphenyl)-HCID 24526Chlorine

생성물 1

HCID 18487p-Chloro-o-toluidine hydrochloride수율 132.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

79 g (1.1 moles) of chlorine is introduced into a solution of 135 g (1 mole) of 2 -formylaminotoluene in 500 ml of chloroform at 20° to 25° C. in the course of 2 to 3 hours. After the addition of 28 g (0.88 mole) of methanol, the mixture obtained is stirred for 2 hours at 25° to 30° C., and the formed 2 -amino-5 -chlorotoluene hydrochloride is subsequently filtered off. There is obtained 130 g (73% of theory relative to 2 -formylaminotoluene) of 2 -amino-5 -chlorotoluene hydrochloride. The content of 2 -amino-5 -chlorotoluene hydrochloride in the product is 98 to 99%.

후처리

  1. customthe mixture obtained
  2. filtrationthe formed 2 -amino-5 -chlorotoluene hydrochloride is subsequently filtered off

출처 및 근거

ORD 기록
ord-224e2f4cc30946509a1b5f6797145d9f
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04034043

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