Hydrochloric Acid → N-Methyl-N'-hydroxy-N"-[4-(4-imidazolyl)butyl]guanidine dihydrochloride

HRID 258747

반응식

HRID 258747 반응식
[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[N:11]=[CH:12][NH:13][CH:14]=1)=S.[ClH:15].Cl.Cl.[OH:18][NH:19]C(NC)=NCCSCC1NC=NC=1C.CNC(=NCCCCC1N=CNC=1)SC.NO.Cl.Cl.Cl.ON(CCSCC1NC=NC=1C)C(N)=NCCSCC1NC=NC=1C>>[ClH:15].[ClH:15].[CH3:1][NH:2][C:3]([NH:19][OH:18])=[N:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[N:11]=[CH:12][NH:13][CH:14]=1

참가 물질

7

반응물 6

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 178433318HCID 178433318, 화합물HCID 178484951N,S-dimethyl-N'-[4-(4-imidazolyl)butyl]isothioureaHCID 178485010HCID 178485010, 화합물HCID 178486108N-[4-(1H-imidazol-5-yl)butyl]-N'-methylcarbamimidothioic acid

생성물 1

HCID 178484950N-Methyl-N'-hydroxy-N"-[4-(4-imidazolyl)butyl]guanidine dihydrochloride

실험 절차

When N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea is reacted with methanolic hydrogen chloride by the procedure of Example 1 (i) the product is N,S-dimethyl-N'-[4-(4-imidazolyl)butyl]isothiourea which on treatment with hydroxylamine by the procedure of Example 1 (ii) gives the title product.

출처 및 근거

ORD 기록
ord-fd4cd49e80f243f4a28bbc91dd8a0049
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04034101

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