Water → 4-(Methylsulfanyl)-2-nitroaniline

HRID 258758노트

반응식

HRID 258758 반응식
[N+:1]([C:4]1[CH:10]=[C:9]([S:11][C:12]#N)[CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].[OH-].[K+].CI.O>C(O)C>[CH3:12][S:11][C:9]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:1]([O-:3])=[O:2])[CH:10]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 1046774-Amino-3-nitrophenyl thiocyanate

생성물 1

HCID 108886074-(Methylsulfanyl)-2-nitroaniline수율 95.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Nitro-4-thiocyanato-aniline (17.6 g.) was added portionwise to a stirred solution of potassium hydroxide (13.4 g.) in ethanol (210 ml.) cooled below 15° C. After 5 minutes, methyl iodide (12.8 g.) was added to the purple solution and the mixture was allowed to stand overnight at room temperature. The mixture was then poured into water (1100 ml.) and the deep red solid was filtered off, washed with water, and dried to give 4-methylthio-2-nitroaniline (15.8 g.), m.p. 72°-73° C.

후처리

  1. temperaturecooled below 15° C
  2. waitto stand overnight at room temperature
  3. filtrationthe deep red solid was filtered off
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-5f1d566e205e4d2797ad974e92ce3565
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04034107

반응 노트

불러오는 중…