Sodium Carbonate → 2-[3-Bis(2-hydroxyethyl)aminopropyl]amino-quinoline

HRID 258815

반응식

HRID 258815 반응식
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[OH:12][CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH2:21][NH2:22])[CH2:16][CH2:17][OH:18].C(=O)([O-])[O-].[Na+].[Na+]>C(O)(C)C>[OH:18][CH2:17][CH2:16][N:15]([CH2:14][CH2:13][OH:12])[CH2:19][CH2:20][CH2:21][NH:22][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 119282-ChloroquinolineHCID 21088(3-Aminopropyl)diethanolamine

생성물 1

HCID 214246762-[3-Bis(2-hydroxyethyl)aminopropyl]amino-quinoline

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 5.05 g. of 2-chloroquinoline, 5.5 g. of bis(2-hydroxyethyl)aminopropylamine and 3.0 g. of sodium carbonate is heated in 20 ml. of refluxing isopropanol for 24 hours. The reaction mixture is then filtered, solvent removed in vacuo and the residue chromatographed over silica gel to obtain an oil of 2-[3-bis(2-hydroxyethyl)aminopropyl]amino-quinoline.

후처리

  1. additionA mixture of 5.05 g
  2. filtrationThe reaction mixture is then filtered
  3. customsolvent removed in vacuo
  4. customthe residue chromatographed over silica gel

출처 및 근거

ORD 기록
ord-03178fbcc19d4bcd8274cb500c301743
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04035367

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