Hydrochloric Acid → Ethyl p-(2-thenoyl)hydratropate

HRID 258888

반응식

HRID 258888 반응식
[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:20](O)[CH3:21]>>[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([O:15][CH2:20][CH3:21])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 5359Suprofen

생성물 1

HCID 12232951Ethyl p-(2-thenoyl)hydratropate

실험 절차

A mixture of 5.2 parts of p-(2-thenoyl)hydratropic acid, 40 parts of absolute denatured ethanol and 0.5 parts of hydrochloric acid solution is stirred and refluxed for 24 hours. The reaction mixture is evaporated and the residue is taken up in ether. The ethereal solution is shaken with alkaline water, separated and shaken twice with water. The ether phase is dried, filtered and evaporated, yielding ethyl p-(2-thenoyl)hydratropate, also named ethyl p-(2-thenoyl)-α-methyl-phenylacetate, as a residue.

후처리

  1. temperaturerefluxed for 24 hours
  2. customThe reaction mixture is evaporated
  3. stirringThe ethereal solution is shaken with alkaline water
  4. customseparated
  5. stirringshaken twice with water
  6. dry with materialThe ether phase is dried
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-925f1d235b844c00a8f0250c8471af8f
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04035376

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