Hydrochloric Acid → Suprofen

HRID 258904

반응식

HRID 258904 반응식
CC(N)C1C=CC=CC=1.[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1.Cl>O>[C:10]1([C:15]([C:17]2[CH:27]=[CH:26][C:20]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=2)=[O:16])[S:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 70638167(+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

생성물 1

HCID 5359Suprofen

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1 part of (+)-p-(2-thenoyl)hydratropic acid α-methylbenzylamine is suspended in water and acidified with hydrochloric acid. The product is extracted with ether. The organic layer is washed with water, dried, filtered and evaporated in vacuo. The oily residue solidifies on triturating in petroleumether. The solidified product is filtered off and dried in vacuo at 50° C, yielding (-)-p-(2-thenoyl)hydratropic acid; [α] (1% MeOH) =MeOH)= -45.6°.

후처리

  1. extractionThe product is extracted with ether
  2. washThe organic layer is washed with water
  3. customdried
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customon triturating in petroleumether
  7. filtrationThe solidified product is filtered off
  8. customdried in vacuo at 50° C

출처 및 근거

ORD 기록
ord-2c53f8e24b814c87a7c9ecb3767b3d63
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04035376

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