Hydrochloric Acid → HCID 20211459, 화합물

HRID 258935노트

반응식

HRID 258935 반응식
[Cl:1][C:2]1[C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:11].[S:12]1[CH:16]=[CH:15][CH:14]=[CH:13]1.Cl>C(Cl)Cl>[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:8]([C:7]1[C:2]([Cl:1])=[C:3]([CH3:11])[CH:4]=[CH:5][CH:6]=1)=[O:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8030ThiopheneHCID 193679402-Chloro-3-methylbenzoyl chloride

생성물 1

HCID 20211459HCID 20211459, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred and cooled mixture of 28.4 parts of 2-chloro-m-toluoyl chloride, 12.6 parts of thiophene and 80 parts of methylene chloride is added dropwise a mixture of 39 parts of stannic chloride in 40 parts of methylene chloride at 10° C. Upon completion, stirring is continued first for 2 hours a 20° C and further for 3 hours at reflux. The reaction mixture is poured onto a mixture of ice-water and concentrated hydrochloric acid solution. The methylene chloride solution is separated, washed three times with water, dried, filtered and evaporated. The residue is distilled, yielding 2-chloro-m-tolyl 2-thienyl ketone; bp. 197° -199° C at 12 mm. pressure.

후처리

  1. temperaturecooled
  2. additionis added dropwise
  3. stirringUpon completion, stirring
  4. temperatureat reflux
  5. customThe methylene chloride solution is separated
  6. washwashed three times with water
  7. customdried
  8. filtrationfiltered
  9. customevaporated
  10. distillationThe residue is distilled

출처 및 근거

ORD 기록
ord-81a4aabba73b40feadf3466912b052f6
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04035376

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