Hydrochloric Acid → Dimethylmalonyl Dichloride

반응식

[CH3:1][C:2]([CH3:9])([C:6](O)=[O:7])[C:3](O)=[O:4].S(Cl)([Cl:12])=O.[ClH:14].S(=O)=O>>[CH3:1][C:2]([CH3:9])([C:6]([Cl:12])=[O:7])[C:3]([Cl:14])=[O:4]

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 1119Sulfur Dioxide

HCID 11686Dimethylmalonic acid2회

HCID 24386Thionyl Chloride

생성물 1

HCID 4523180Dimethylmalonyl Dichloride

실험 절차

To a 500 ml. one-necked flask equipped with reflux condenser with drying tube, is added 50 grams (0.38 mole) dimethylmalonic acid (Aldrich Chemical Co.) and 300 ml. thionyl chloride. The mixture is heated to reflux for about 1 hour during which time the dimethylmalonic acid is dissolved and hydrogen chloride and sulfur dioxide are evolved. The unreacted thionyl chloride is removed by distillation under reduced pressure. The residue is recrystallized twice from cyclohexane to yield a white solid, M.P. 186°-187° C.

후처리

customone-necked flask equipped
temperaturewith reflux condenser
customwith drying tube
temperatureThe mixture is heated
dissolutionis dissolved
customThe unreacted thionyl chloride is removed by distillation under reduced pressure
customThe residue is recrystallized twice from cyclohexane
customto yield a white solid, M.P. 186°-187° C.

출처 및 근거

ORD 기록: ord-38581de9b1114be4935b945dafac826a
출처 데이터셋: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04035437

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