Quinoline → Isoquinoline

HRID 259079

반응식

HRID 259079 반응식
CC(OCC1CS[C@@H]2[C@H](NC(CCC[C@@H](N)C(O)=O)=O)C(=O)N2C=1C(O)=O)=O.[N:29]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:32]=[CH:31][CH:30]=1>[Cl-].[Na+]>[CH:38]1[C:33]2[C:32](=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:31]=[CH:30][N:29]=1

참가 물질

4

반응물 2

HCID 7047QuinolineHCID 65536Cephalosporin C

생성물 1

HCID 8405Isoquinoline

시약·촉매·용매 1

HCID 5234Sodium Chloride용매

실험 절차

15 ml of the remaining reaction solution were diluted with 5% sodium chloride solution to make 30 ml (corresponds to 0.5% solution calculated as cephalosporin C). After adding 0.22 ml of quinoline to the solution, the mixture was adjusted to pH 3.0 and stirred at 5 - 10° C. Very soon crystals are separated out. The crystals were collected after an hour, washed with ice-water and with ethyl acetate and dried in vacuo. 226 mg of isoquinoline adduct of N-methylthioacetyl-cephalosporin C having 97% purity were obtained.

후처리

  1. custom15 ml of the remaining reaction solution
  2. customVery soon crystals are separated out
  3. customThe crystals were collected after an hour
  4. washwashed with ice-water and with ethyl acetate
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-c9cb96fd44074840bf3b3fb02d3679d6
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04036833

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