Salicylamide → 2,2-dimethyl-3,4-dihydro-2H-1,3-benzoxazin-4-one
반응식
C(Cl)(Cl)Cl.[C:5]([NH2:14])(=[O:13])[C:6]1[C:7](=[CH:9][CH:10]=[CH:11][CH:12]=1)[OH:8].O.[C:16]1(C)[C:17](S(O)(=O)=O)=CC=C[CH:21]=1>CC(C)=O>[CH3:21][C:16]1([CH3:17])[NH:14][C:5](=[O:13])[C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[O:8]1참가 물질
5
실험 절차
A 500-ml flask was charged with 250 ml of chloroform, 27.4 g (0.2 mol) of salicylamide, 23.2 g (0.4 mol) of acetone and 2.7 g of toluene sulfonic acid monohydrate. The flask was equipped with a Soxhlet extraction vessel containing 36.7 g of molecular sieves (Linde Type 3A, 1/16 inch) in the thimble. The reaction mixture was refluxed for 24 hours. Then fresh sieves were placed in the Soxhlet and 10 g of acetone was added to the reaction mixture. Reflux was continued for 24 hours.
후처리
- customThe flask was equipped with a Soxhlet extraction vessel
- temperatureThe reaction mixture was refluxed for 24 hours
- additionwas added to the reaction mixture
- temperatureReflux
출처 및 근거
- ORD 기록
- ord-b2ffb7e073fb4b8f88697099e8fecc7d
- 출처 데이터셋
- uspto-grants-1977_07
- 특허 번호
- US04036960
반응 노트
불러오는 중…