1-Dodecanethiol → 1-(n-Dodecylthio)-3-isopropoxy-2-propanol

HRID 259267

반응식

HRID 259267 반응식
[CH:1]([O:4][CH2:5][CH:6]1[O:8][CH2:7]1)([CH3:3])[CH3:2].[H-].[Na+].[CH3:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][SH:23]>O1CCCC1>[CH2:22]([S:23][CH2:7][CH:6]([OH:8])[CH2:5][O:4][CH:1]([CH3:2])[CH3:3])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH3:11]

참가 물질

5

반응물 3

HCID 81951-DodecanethiolHCID 199202-((1-Methylethoxy)methyl)oxiraneHCID 24758Sodium hydride

생성물 1

HCID 214239641-(n-Dodecylthio)-3-isopropoxy-2-propanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
60 °C

실험 절차

2,3-Epoxypropyl isopropyl ether (1.16 g.) in several ml. of dry tetrahydrofuran is added to a stirred suspension formed by the addition of 50 mg. of sodium hydride (56% dispersion in mineral oil) to 2.2 g. 8. of n-dodecylthiol in 50 ml. tetrahydrofuran. The mixture is then stirred at 60° C. After approximately 4 hours the solvent is removed from the reaction mixture and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the ether extracts washed with water, dried over magnesium sulfate and evaporated to yield 1-(n-dodecylthio)-3-isopropoxy-2-propanol.

후처리

  1. customformed by the addition of 50 mg
  2. customAfter approximately 4 hours the solvent is removed from the reaction mixture and 20 ml
  3. additionof water is added to the residue
  4. extractionThe resultant aqueous mixture is extracted with ether
  5. washthe ether extracts washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated

출처 및 근거

ORD 기록
ord-1f4109b6444941dcb8d0392730d445b1
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04036974

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